2D Healthcare
2D Healthcare
I-Cell Networks · Japan
I-Cell Networks Japan — Exclusive Representative in Türkiye

Japan's most advancedcancer treatments,now one step away.

CAR-T, iPSC, BNCT, heavy ion and proton therapy — 2D Healthcare, Türkiye representative of Japan's accredited coordinator I-Cell Networks, manages your journey with the highest discretion and care: medical visa, private interpreter, accommodation and follow-up — every detail considered for you.

12
Advanced therapies
17
Partner centers
24/7
Turkish support
FEATURED TECHNOLOGY

Personalized Cancer Vaccine — AFTV

Prepared in Japan from your own tumor tissue, the vaccine teaches your immune system to recognize the tumor. Low side-effect profile, outpatient application.

  • Made from your own tumor
  • Trains your immune system
  • Custom production in Japan
Explore the Vaccine
Personalized Cancer Vaccine — AFTV
健康Health
善Goodness
癒Healing
和Harmony
命Life
心Heart
絆Bond
未来Future
健康Health
善Goodness
癒Healing
和Harmony
命Life
心Heart
絆Bond
未来Future
INTRODUCTION

Meet Tudi — the guide of your journey

By your side from application to treatment: answers your questions, explains the process, shows you the way.

Hello! I'm Tudi

Your journey's guide

Tudi
CAR-T
iPSC / iCART
BNCT
HEAVY ION
PROTON
AFTV VACCINE
NK CELL
PHOTO-IMMUNO
CATHETER / IVR
HYPERTHERMIA
STEM CELL
SURGERY
SECOND OPINION
CAR-T
iPSC / iCART
BNCT
HEAVY ION
PROTON
AFTV VACCINE
NK CELL
PHOTO-IMMUNO
CATHETER / IVR
HYPERTHERMIA
STEM CELL
SURGERY
SECOND OPINION

In Japan, international patients cannot apply directly; an accredited coordinator is mandatory. We are I-Cell Networks' exclusive representative in Türkiye.

Tumor Guide

Which treatment for which tumor?

Select your diagnosis type and see the most preferred methods from the Japan portfolio. Final eligibility always depends on the evaluation of Japanese physicians.

Treatment Portfolio

Unique in the world. Precise. Evidence-based.

Japan has the world's most advanced infrastructure in cellular and particle therapies. Here are the doors we open for our patients — the full I-Cell Networks portfolio.

PiggyBac CAR-T Cell Therapy
Cell & Gene Therapy

PiggyBac CAR-T Cell Therapy

Investigational

Virus-free gene transfer — pioneered in Japan

Transposon (piggyBac) technology replaces expensive lentiviral vectors of conventional CAR-T manufacturing, lowering cost and simplifying strict GMP processes.

  • Virus-free, safer manufacturing
  • More accessible cost
  • High efficacy in blood cancers
LeukemiaLymphomaMultiple Myeloma
iPSC-Derived CAR-T (iCART)
Stem Cell & Regenerative

iPSC-Derived CAR-T (iCART)

Investigational

Nobel-winning iPSC technology — CiRA Kyoto & Takeda

The iPSC technology that earned Shinya Yamanaka the Nobel Prize became the iCART program at Kyoto University's CiRA under Dr. Shin Kaneko, then advanced globally with Takeda. Unlimited, standardized CAR-T cells from a single cell line.

  • Ready off-the-shelf cells
  • Kyoto CiRA + Takeda collaboration
  • Japan granted first iPSC approvals in 2026
B-cell LymphomaBlood Cancers
BNCT — Boron Neutron Capture Therapy
Particle Beam Therapy

BNCT — Boron Neutron Capture Therapy

Approved treatment

Cell-level selectivity, often a single session

A boron compound accumulates in tumor cells; a neutron beam destroys only the boron-loaded cells, sparing healthy tissue almost entirely. Japan was the first country to approve BNCT for routine clinical use in 2020.

  • Usually one session is enough
  • Spares healthy tissue
  • Osaka University clinical center
Brain TumorsRecurrent Head & NeckMeningioma
Carbon (Heavy) Ion Radiotherapy
Particle Beam Therapy

Carbon (Heavy) Ion Radiotherapy

Approved treatment

QST Chiba — over 12,000 patients since 1994

Carbon ions deposit maximum energy at the tumor's depth (Bragg peak). Surgery-free, high local control in challenging tumors such as pancreas, liver, bone & soft tissue and prostate. Published series report 5-year local control above 90% in prostate cancer.

  • Indicated for 12 cancer types
  • Short courses (1–3 weeks)
  • 6 heavy ion centers in Japan
PancreasProstateLiverBone & Soft TissueLungHead & Neck
Proton Beam Therapy
Particle Beam Therapy

Proton Beam Therapy

Approved treatment

Millimetric precision — gold standard for children and sensitive organs

Protons leave almost no dose beyond the target. Minimizes long-term side effects in tumors near the brain and spinal cord, and in pediatric patients. University of Tsukuba PMRC is Japan's most established proton center.

  • Minimal dose to surrounding organs
  • Preferred in pediatric oncology
  • Tsukuba PMRC, NCC East, Medipolis
Pediatric TumorsBrain & Spine AreaHead & NeckLiverEsophagus
AFTV — Personalized Cancer Vaccine
Immunotherapy

AFTV — Personalized Cancer Vaccine

Private clinic practice

A vaccine made from your own tumor tissue

Prepared from the patient's own tumor tissue, the vaccine carries all tumor antigens rather than a single one, naturally training the immune system. Aims to reduce recurrence risk after surgery.

  • Fully personalized production
  • Covers all tumor antigens
  • Builds immune memory
Post-surgery Recurrence PreventionAll Solid Tumors
Cellular Immunotherapy (NK & Dendritic Cell)
Immunotherapy

Cellular Immunotherapy (NK & Dendritic Cell)

Private clinic practice

Re-arming the immune system

NK (natural killer) cell and dendritic cell therapies multiply and strengthen the patient's own immune cells in the lab and return them. A supportive option alongside standard treatments or a new path when options run out.

  • NK cell transfer
  • Dendritic cell vaccine
  • Combination with standard care
Various Solid TumorsSupportive Care
Photo-Immunotherapy (Light-Based Cancer Therapy)
Immunotherapy

Photo-Immunotherapy (Light-Based Cancer Therapy)

Approved treatment

Hikari Clinic, Tokyo — photosensitizer + light

A light-sensitive agent given intravenously accumulates in cancer cells; light applied to the region selectively destroys only cancer cells through a photochemical reaction, then activates the body's own immune response against the tumor.

  • Surgery-free, minimally invasive
  • Applicable to 20+ cancer types
  • Trains the immune system against the tumor
PancreasLungColorectalStomachBreastProstateEsophagusMelanoma
Incision-Free Intravascular Therapy & Hyperthermia
Interventional Therapy

Incision-Free Intravascular Therapy & Hyperthermia

Private clinic practice

IGT Clinic, Osaka — direct to the tumor via catheter

A hair-thin catheter advanced from the groin reaches the artery feeding the tumor; medication is delivered directly to cancer cells and the feeding vessel is blocked. Combined with hyperthermia (heat therapy) and immunotherapy, the effect is amplified. A low-burden option for recurrence and metastasis.

  • No general anesthesia, no incision
  • Focused on recurrence & metastasis
  • Combined with hyperthermia and immunotherapy
LiverLungMetastatic TumorsRecurrent Lesions
Regenerative Medicine & Stem Cell Therapies
Stem Cell & Regenerative

Regenerative Medicine & Stem Cell Therapies

Investigational

Japan's national hallmark — iPSC infrastructure

In early 2026, Japan made history by granting the world's first official approvals for iPSC-derived therapies (Parkinson's and heart failure). The same mature infrastructure is open to patients in orthopedic, neurological and tissue-repair stem cell applications.

  • World's first iPSC approvals
  • GMP-certified cell processing
  • Expanding list of indications
Tissue RepairOrthopedic SupportNeurological Programs
Advanced Oncological Surgery
Surgery

Advanced Oncological Surgery

Approved treatment

Robotic and minimally invasive approach

Robotic (da Vinci) and laparoscopic cancer surgery at Japan's reference university hospitals — experienced teams, short hospital stays and meticulous post-operative protocols. You are referred to the right center through I-Cell Networks coordination.

  • Robotic & laparoscopic options
  • University hospital standard
  • Post-surgery follow-up plan
StomachColorectalLungEsophagusGynecological
AinPros® Exosome Support Therapy
Stem Cell & Regenerative

AinPros® Exosome Support Therapy

Private clinic practice

Sinclair Ginza Clinic, Tokyo — cell-free regenerative support

AinPros®, produced by Advalife Science, contains exosomes derived from stem cell culture and over 2,000 bioactive substances (growth factors, cytokines). Applied via IV drip or locally, it supports tissue repair, inflammation reduction and immune balance.

  • Cell-free formula
  • ISO 17025 accredited production
  • An unapproved private (self-pay) therapy in Japan
Chronic Pain & FatigueTissue Repair SupportImmune Balance
Japan in Numbers

Experience, proven by numbers.

12.000+

patients treated with heavy ions at QST since 1994

6

heavy ion centers in Japan — roughly half of the world's

2020

Japan became the first country to approve BNCT for routine clinical use

%90+

5-year local control in prostate cancer with heavy ions (published series)

İlk

world's first iPSC therapy approvals were granted in Japan in 2026

20+

cancer types addressable with photo-immunotherapy

Source: clinical data published by the centers and public institutional reports.

Partner Centers

Japan's reference centers, under one roof.

Heavy Ion

QST Hospital (Chiba)

World's first heavy ion center — 12,000+ patients

Heavy Ion

Gunma University Heavy Ion Medical Center

High-precision scanning beam

Heavy Ion

Osaka Heavy Ion Therapy Center

Reference center of western Japan

Heavy Ion

Kanagawa Cancer Center

Close to the Tokyo metro area

Heavy Ion

Yamagata University East Japan Heavy Ion Center

East Japan center

Heavy Ion

Hyogo Ion Beam Medical Center

University-backed center in Kobe

Proton

National Cancer Center Hospital East

Japan's apex oncology institution

Proton

University of Tsukuba Hospital (PMRC)

Japan's most established proton center

Proton

Southeast Tohoku Proton Therapy Center

Koriyama, Fukushima

Proton

Medipolis Proton Therapy Center

Kagoshima — treatment & stay campus

Clinic

Osaka University BNCT Clinical Center

Home of BNCT in routine clinical care

Clinic

KEK (Tsukuba)

Neutron source research infrastructure

Clinic

CiRA — Kyoto University

World center of iPSC research

Clinic

Hikari Clinic (Tokyo)

Photo-immunotherapy & advanced immunotherapy

Clinic

IGT Clinic (Osaka Rinku)

Incision-free catheter therapy, hyperthermia, regenerative medicine

Clinic

Sinclair Ginza Clinic (Tokyo)

AinPros® exosome support therapy — Ginza

Clinic

Ginza Namiki-dori Clinic (Tokyo)

Low-dose chemo, autologous cancer vaccine, cancer dormancy therapy, second opinion — Ginza

Clinical Atmosphere

Your treatment, surrounded by the world's most advanced technology

A journey through Japan's university hospitals — alongside robotic systems, particle therapy centers and personalized medicine labs.

University hospitals
Advanced imaging & labs
Turkish medical escort
How It Works

Six steps from application to treatment.

1

Apply & Upload

Register on the portal and securely upload your reports and scans.

2

Medical Pre-Evaluation

Your documents are translated into Japanese and sent to the expert board. Response within 5 business days.

3

Plan & Transparent Offer

You receive the suitable center, treatment plan and a clear cost offer.

4

Visa & Travel

Medical stay visa, flights, accommodation and transfers are arranged by us.

5

Treatment in Japan

An interpreter accompanies every consultation; payments are secured via the coordinator.

6

Follow-up in Türkiye

Post-return control plan and the bridge to Japan stay with us.

PROCESS WIZARD

Select a diagnosis, see your roadmap

Select the diagnosis; we instantly show the suitable Japanese treatments and a step-by-step timeline. No prices — the cost is finalized with a written offer after the expert board review.

Patient Experiences

Journeys that reached Japan.

Short stories from our patients' treatment journeys across different diagnoses.

"I was told I needed surgery; I got through it without a scalpel thanks to three weeks of heavy ion therapy. My interpreter was by my side every day, everything ran like clockwork."
M.K.58 · Ankara — Prostate, Heavy Ion (QST)
"By my third recurrence I had little hope left. I had a single BNCT session; the next day I was sightseeing. They handled everything, including translating my reports into Japanese."
S.A.47 · Istanbul — Recurrent Head & Neck, BNCT
"I uploaded my reports through the portal and had the Japanese board's evaluation within five days. At every step I knew what would happen next."
E.Y.34 · Izmir — Lymphoma, CAR-T Evaluation
"Chemo was my only remaining option for metastasis. After incision-free catheter therapy and hyperthermia we reached our targets; my follow-up continued back home."
R.H.61 · Bursa — Colon Metastasis, Catheter Therapy (IGT)

Stories are published anonymized for privacy.

REAL STORIES

Our patients treated in Japan tell their story

Real patients, real experiences — in their own words, on camera.

Blog & News

Latest developments from Japan.

Approvals, clinical innovations and updates in our treatment portfolio.

Second Opinion

Let Japan's specialists review your reports.

Free preliminary evaluation within 5 business days.

a. info@2dhealthcare.com
b. +90 538 541 11 02 · +90 538 541 10 01 · +90 531 670 24 60
c. Küçük Çamlıca Mah. Vefakar Sok. No:1, Üsküdar / İstanbul
Onam & Sözleşme
Frequently Asked Questions

Everything on your mind, answered.

Legal Documents

Transparency, on paper too.

Consent forms, KVKK notice and the remote service agreement. Review, download, and upload the signed copy via your portal.

KVKK / Personal Data

KVKK Personal Data Consent Form (JP/EN original)

Governs how your personal data (identity, contact, diagnosis, test results, imaging, treatment information) is processed within medical tourism, the conditions of transfer to healthcare institutions in Japan, and your rights (disclosure, correction, deletion, suspension of use).

Service Agreement

International Healthcare Intermediary Service Agreement

Sets out in 12 articles that 2D Healthcare provides no medical services; covers intermediary services such as applications, communication, travel and accommodation organization, fee-refund terms, data transfer consent, and the parties' obligations.

2D Healthcare Magazine

Japan Health Magazine

The Japan Difference in Cancer Care

2D Healthcare
2D Healthcare

Your gateway to Japan's advanced therapies.

info@2dhealthcare.com
+90 538 541 11 02 · +90 531 670 24 60
Küçük Çamlıca Mah. Vefakar Sok. No:1, 34696 Üsküdar / İstanbul
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2D Healthcare does not provide medical diagnosis or treatment; it provides coordination and organization services only. All medical decisions belong to licensed physicians in Japan.

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